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fases de crecimiento del cabello humano <a href=http://hairgrowth.cf/es/que-motiva-el-crecimiento-del-cabello-12.html>que motiva el crecimiento del cabello 12</a> <a href=http://hairgrowth.cf/es/crecimiento-del-cabello-nuevo-6.html>crecimiento del cabello nuevo 6</a> <a href=http://hairgrowth.cf/es/trucos-para-el-crecimiento-del-cabello-mas-rapido/crecimiento-del-pelo-medicamento.html>crecimiento del pelo medicamento</a> En experimentos en ratones, investigadores de la Universidad de California (UC) San Francisco, en Estados Unidos, han descubierto que las cГ©lulas T reguladoras, un tipo de cГ©lula inmunolГіgica generalmente asociada con el control de la inflamaciГіn, desencadenan directamente cГ©lulas madre en la piel para promover el crecimiento sano del cabello. Sin estas cГ©lulas inmunes como socias, las cГ©lulas madre no pueden regenerar los folГ­culos pilosos, lo que lleva a la calvicie, segГєn hallaron los cientГ­ficos. 'Nuestros folГ­culos pilosos se estГЎn reciclando constantemente: cuando se cae un pelo, todo el folГ­culo piloso tiene que volver a crecer', afirma el autor del documento, Michael Rosenblum, profesor asistente de DermatologГ­a en UCSF. 'Se ha pensado que esto es un proceso enteramente dependiente de las cГ©lulas madre, pero resulta que las Treg son esenciales. Si se bloquea este tipo de cГ©lulas inmunes, el pelo no crece'. El nuevo estudio (publicado en la ediciГіn digital de este viernes de Cell) sugiere que los defectos en Tregs podrГ­an ser responsables de la alopecia areata, un desorden autoinmune comГєn que cause la pГ©rdida del pelo, y podrГ­an jugar un papel en otras formas de calvicie, segГєn Rosenblum. Dado que las mismas cГ©lulas madre son responsables de ayudar a sanar la piel despuГ©s de una lesiГіn, el trabajo plantea la posibilidad de que Tregs tambiГ©n pueden desempeГ±ar un papel clave en la reparaciГіn de heridas. Normalmente, las Treg actГєan como guardianes de la paz y diplomГЎticos, informando al resto del sistema inmunolГіgico de la diferencia entre amigo y enemigo. Cuando Tregs no funcionan correctamente, se pueden desarrollar alergias a sustancias inofensivas como la proteГ­na de cacahuete o la caspa del gato, o sufrir trastornos autoinmunes en los que el sistema inmunolГіgico ataca los propios tejidos del cuerpo. Al igual que otras cГ©lulas inmunes, la mayorГ­a de las Tregs residen en los ganglios linfГЎticos del cuerpo, pero algunas viven permanentemente en otros tejidos, donde parecen haber evolucionado para ayudar con las funciones metabГіlicas locales, asГ­ como desempeГ±ar su funciГіn antiinflamatoria normal. En la piel, por ejemplo, Rosenblum y colegas han demostrado previamente que Tregs ayuda a establecer la tolerancia inmune a los microbios sanos de la piel en ratones reciГ©n nacidos y estas cГ©lulas tambiГ©n segregan las molГ©culas que ayudan con la curaciГіn de las heridas en edad adulta. Es como si las cГ©lulas madre de la piel y Tregs hayan coevolucionado, por lo que las Treg no sГіlo protegen las cГ©lulas madre contra la inflamaciГіn, sino que tambiГ©n participan en su trabajo regenerativoRosenblum, que es a la vez inmunГіlogo y dermatГіlogo, querГ­a entender mejor el papel de estas cГ©lulas inmunes residentes en la salud de la piel. Para ello, Г©l y su equipo desarrollaron una tГ©cnica para eliminar temporalmente Tregs de la piel, pero cuando rasparon manchas de pelo de estos ratones para hacer observaciones de la piel afectada, hicieron un descubrimiento sorprendente. 'RГЎpidamente nos dimos cuenta de que las zonas afeitadas nunca volvГ­an a crecer y pensamos que podrГ­a ser interesante. Nos dimos cuenta de que tenГ­amos que ahondar en esto mГЎs', relata Rosenblum. En la nueva investigaciГіn, liderada por el investigador postdoctoral de UCSF y primer autor Niwa Ali, surgieron varias lГ­neas de evidencia de que Tregs desempeГ±a un papel en el desencadenamiento de la regeneraciГіn del folГ­culo piloso. En primer lugar, los experimentos de imagen revelaron que las Treg tienen una estrecha relaciГіn con las cГ©lulas madre que residen dentro de los folГ­culos pilosos y les permiten regenerarse: el nГєmero de Tregs activas que se agrupan alrededor de las cГ©lulas madre del folГ­culo se multiplica normalmente por tres veces cuando los folГ­culos entran en la fase de crecimiento de su ciclo regular de descanso y regeneraciГіn. AdemГЎs, la eliminaciГіn de Tregs de la piel bloqueГі el rebrote del cabello sГіlo si esto se hizo dentro de los tres primeros dГ­as despuГ©s de afeitar un trozo de piel, cuando la regeneraciГіn folicular se activarГ­a normalmente. Deshacerse de Tregs mГЎs tarde, una vez que la regeneraciГіn ya habГ­a comenzado, no tuvo ningГєn efecto sobre el crecimiento del cabello. El papel de Treg en el desencadenamiento del crecimiento del pelo no parecГ­a relacionado con su capacidad normal de reducir la inflamaciГіn de los tejidos, hallaron los investigadores. En su lugar, descubrieron que Tregs desencadenan la activaciГіn de cГ©lulas madre directamente a travГ©s de un sistema de comunicaciГіn celular comГєn conocido como el camino Notch. Los investigadores demostraron que Tregs en la piel expresan niveles inusualmente altos de una proteГ­na de seГ±alizaciГіn Notch llamada Jagged 1 (Jag1), en comparaciГіn con Tregs en otras partes del cuerpo. Luego, demostraron que la eliminaciГіn de Tregs de la piel redujo significativamente la seГ±alizaciГіn Notch en las cГ©lulas madre del folГ­culo y que la sustituciГіn de Tregs con perlas microscГіpicas cubiertas por la proteГ­na Jag1 restaurГі la seГ±alizaciГіn Notch en las cГ©lulas madre y activГі con Г©xito la regeneraciГіn folicular. 'Es como si las cГ©lulas madre de la piel y Tregs hayan coevolucionado, por lo que las Treg no sГіlo protegen las cГ©lulas madre contra la inflamaciГіn, sino que tambiГ©n participan en su trabajo regenerativo (dice Rosenblum). Ahora, las cГ©lulas madre dependen totalmente de las Treg para saber cuГЎndo es el momento de comenzar a regenerarse'. Rosenblum dice que los resultados pueden tener implicaciones para la alopecia areata, una enfermedad autoinmune que interfiere con la regeneraciГіn del folГ­culo piloso y hace que los pacientes pierdan el pelo en partes de su cuero cabelludo, las cejas y las caras. La alopecia estГЎ entre las enfermedades autoinmunes humanas mГЎs comunes (es tan comГєn como la artritis reumatoide y mГЎs comГєn que la diabetes tipo 1), pero los cientГ­ficos tienen poca idea de quГ© lo causa. DespuГ©s de que su equipo observГі por primera vez la pГ©rdida de cabello en ratones deficientes en Treg, Rosenblum aprendiГі que los genes asociados con la alopecia en estudios anteriores estГЎn casi todos vinculados con Tregs y los tratamientos que aumentan la funciГіn Treg han demostrado ser un tratamiento eficaz para la enfermedad. Rosenblum especula que entender mejor el papel crГ­tico de Tregs en el crecimiento del cabello podrГ­a conducir a mejores tratamientos para la pГ©rdida de cabello mГЎs generalmente. El estudio tambiГ©n se suma a un creciente sentido de que las cГ©lulas inmunes desempeГ±an papeles mucho mГЎs amplios en la biologГ­a de tejidos de lo que se habГ­a apreciado anteriormente, aГ±ade este experto, que planea explorar si Tregs en la piel tambiГ©n juegan un papel en la cicatrizaciГіn de heridas, ya que las mismas cГ©lulas madre del folГ­culo estГЎn involucradas en la regeneraciГіn de la piel despuГ©s de la lesiГіn. 'Pensamos en las cГ©lulas inmunes como que entran en un tejido para combatir la infecciГіn, mientras las cГ©lulas madre estГЎn allГ­ para regenerar el tejido despuГ©s de que estГ© daГ±ado. Pero lo que encontramos aquГ­ es que las cГ©lulas madre y las cГ©lulas inmunes tienen que trabajar juntas para hacer posible la regeneraciГіn'. 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